齊留通，≥98％（HPLC）

??【編號(hào)】：128028

??【產(chǎn)品名稱】：齊留通，≥98％（HPLC）

??【規(guī)格】：20MG

??【用途】：

　　齊留通，≥98％（HPLC）

　　Product Name： Zileuton

　　別名：ZYFLO;1-(1-(benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea

　　CAS號(hào)：111406-87-2

　　分子量：236.29

　　介紹： Zileuton

　　貯存：儲(chǔ)存溫度-20°C

　　可溶性：

　　DMSO 47 mg/mL

　　Water <1 mg/mL

　　Ethanol 47 mg/mL

　　生化和生理學(xué)機(jī)理：

　　Description：

　　IC50 Value： N/A

　　zileuton(N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

　　in vitro： Zileuton inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL) (IC50 = 0.5 and 0.3 microM) respectively. It also inhibited leukotriene (LT)B4 biosynthesis by rat PMNL (IC50 = 0.4 microM), human PMNL (IC50 = 0.4 microM) and human whole blood (IC50 = 0.9 microM) [1]. Zileuton inhibited antigen-induced contractions of guinea-pig tracheal strips (GPTS) from actively sensitized animals with an IC50of 6 microM [1].

　　in vivo： Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase [2].&

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齊留通，≥98％（HPLC）

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齊留通，≥98％（HPLC）

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　　齊留通，≥98％（HPLC）

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