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齊留通,≥98%(HPLC)
??【編號(hào)】:128028

??【產(chǎn)品名稱】:齊留通,≥98%(HPLC)

??【規(guī)格】:20MG

??【用途】:

  齊留通,≥98%(HPLC)

  Product Name: Zileuton
  別名:ZYFLO;1-(1-(benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea
  CAS號(hào):111406-87-2
  分子量:236.29
  介紹: Zileuton
  貯存: 儲(chǔ)存溫度-20°C
  可溶性:
  DMSO 47 mg/mL
  Water <1 mg/mL
  Ethanol 47 mg/mL
  生化和生理學(xué)機(jī)理:
  Description:
  IC50 Value: N/A
  zileuton(N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) is a selective and potent 5-LO inhibitor, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.
  in vitro: Zileuton inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL) (IC50 = 0.5 and 0.3 microM) respectively. It also inhibited leukotriene (LT)B4 biosynthesis by rat PMNL (IC50 = 0.4 microM), human PMNL (IC50 = 0.4 microM) and human whole blood (IC50 = 0.9 microM) [1]. Zileuton inhibited antigen-induced contractions of guinea-pig tracheal strips (GPTS) from actively sensitized animals with an IC50of 6 microM [1].
  in vivo: Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase [2].&
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