鹽霉素,≥98%
??【編號(hào)】:126053 ??【產(chǎn)品名稱】:鹽霉素,≥98% ??【規(guī)格】:5MG ??【用途】: 鹽霉素,≥98%
Product Name: Salinomycin
CAS號(hào):53003-10-4
分子式:C42H70O11
分子量:751
介紹: 鹽霉素
貯存: 儲(chǔ)存溫度-20°C
可溶性: DMSO
生化和生理學(xué)機(jī)理:
Description: IC50 Value: Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways[1]. in vitro: Salinomycin acts as a potassium ionophore and thereby interferes with transmembrane potassium potential, leading to mitochondrial and cellular potassium efflux. low concentrations of Salinomycin of 1 μM and 2 μM resulted in haggard and less confluent grown cells, increasing concentrations of Salinomycin of 5 μM and 10 μM resulted in a globular and defragmented cellular phenotype[2]. Treatment of 10.2 ?M Sal for 48 h caused G0/G1 cell cycle arrest in HepG2 cells, whereas 15.3 ?M Sal and 13.8 ?M Sal for 48 h induced G2/M phase arrest in SMMC-7721 and BEL-7402 cells, respectively[3]. in vivo: After administration of 4 mg/kg Sal, 8 mg/kg Sal and 10 ul/g saline wa
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上一篇:Salubrinal, ≥98% | 下一篇:SQ109, ≥99% |
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