鹽霉素，≥98％

??【編號(hào)】：126053

??【產(chǎn)品名稱】：鹽霉素，≥98％

??【規(guī)格】：5MG

??【用途】：

　　鹽霉素，≥98％

　　Product Name： Salinomycin

　　CAS號(hào)：53003-10-4

　　分子式：C42H70O11

　　分子量：751

　　介紹：鹽霉素

　　貯存：儲(chǔ)存溫度-20°C

　　可溶性： DMSO

　　生化和生理學(xué)機(jī)理：

　　Description： IC50 Value： Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways[1]. in vitro： Salinomycin acts as a potassium ionophore and thereby interferes with transmembrane potassium potential, leading to mitochondrial and cellular potassium efflux. low concentrations of Salinomycin of 1 μM and 2 μM resulted in haggard and less confluent grown cells, increasing concentrations of Salinomycin of 5 μM and 10 μM resulted in a globular and defragmented cellular phenotype[2]. Treatment of 10.2 ?M Sal for 48 h caused G0/G1 cell cycle arrest in HepG2 cells, whereas 15.3 ?M Sal and 13.8 ?M Sal for 48 h induced G2/M phase arrest in SMMC-7721 and BEL-7402 cells, respectively[3]. in vivo： After administration of 4 mg/kg Sal, 8 mg/kg Sal and 10 ul/g saline wa

上一篇：Salubrinal, ≥98%		下一篇：SQ109, ≥99%

鹽霉素，≥98％

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鹽霉素，≥98％

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　　鹽霉素，≥98％

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