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Vc-MMAD, ≥99%
??【編號】:125316

??【產(chǎn)品名稱】:Vc-MMAD, ≥99%

??【規(guī)格】:5MG

??【用途】:

  Vc-MMAD, ≥99%

  Product Name: Vc-MMAD
  CAS號:1401963-17-4
  分子式:C70H104N12O14S
  分子量:1369.71
  貯存: 儲存溫度-20°C
  可溶性: 25°C: DMSO
  生化和生理學(xué)機理:
  Description:
  Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.
  For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).
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